Clinical Topics   /   Multiple Sclerosis

Dalfampridine ER Improves Walking in Veterans with MS

USM By U.S. Medicine
March 10, 2014

PORTLAND, OR — In a recent study, Portland VAMC researchers found that, in short-term trials, dalfampridine extended release (ER) improves walking in veterans with multiple sclerosis (MS). In the study, which was published recently in Multiple Sclerosis Journal, the authors noted that the tolerability and effects of dalfampridine-ER in clinical practice had not previously been reported.1 For the study, all patients at the Portland VAMC prescribed dalfampridine-ER over one year completed the Timed 25-Foot Walk (T25FW), Multiple Sclerosis Walking Scale-12 (MSWS-12), Two-Minute Timed Walk (2MTW) and Community Integration Questionnaire (CIQ) at baseline and follow-up clinic visits. Ongoing use and measures were then analyzed. The 39 participants averaged 56.5 years old and were 82% male. Their mean disease duration was 20 years, with 38% having relapsing-remitting MS and 62% progressive MS. According to the results, all measures improved significantly from baseline at initial follow-up — T25FW: -2.7 s, p = 0.004; 2MTW: 41 feet (ft), p = 0.002; MSWS12: -11, p < 0.001; CIQ: 1.2, p = 0.003. After one year, walking endurance and self-perceived walking were significantly improved — 2MTW: 33 ft, p = 0.03; MSWS-12: 5.9, p = 0.007. “Dalfampridine-ER was associated with short-term improvements in walking speed and community participation, and sustained improvements in walking endurance and self-perceived impact of MS on walking for one year,” the authors concluded. “Our study supports the utility of this medication in late MS.” 1Cameron MH, Fitzpatrick M, Overs S, Murchison C, Manning J, Whitham R. Dalfampridine improves walking speed, walking endurance, and community participation in veterans with multiple sclerosis: a longitudinal cohort study. Mult Scler. 2013 Nov 7. [Epub ahead of print] PubMed PMID: 24099749.

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