Clinical Topics   /   Research

AMD Predicts Poorer Overall Survival in Older Women

USM By U.S. Medicine
April 7, 2016

PORTLAND, OR — What is the association between age-related macular degeneration (AMD) and all-cause and cause-specific mortality in a population of older women?

Answering that question was the goal of a prospective cohort study at four U.S. clinical centers. Results were published in the Journal of the American Geriatric Society.1

A study team led by Kaiser Permanente researchers and including participation from the Minneapolis VAMC used a random sample of 1,202 women — mean age 79.5 — with graded fundus photographs at the Year 10 visit of the Study of Osteoporotic Fractures. Researchers graded 45 degree steoscopic fundus photographs for presence of AMD and severity — early vs. late. Death certificates were used to confirm vital status.

According to the findings, prevalence of any AMD was 40.5% at baseline, with 441 patients (36.7%) having early AMD and 46 (3.8%) having late AMD. Over 15 years of follow-up, cumulative mortality was 51.6%.

Results indicate no significant association between AMD presence or severity and all-cause or cause-specific mortality. In women younger than 80, after adjusting for covariates, late AMD was associated with cardiovascular disease (CVD) mortality, with a hazard ratio of 2.61, however.

In women 80 and older, early AMD was associated with all-cause, HR 1.39 and non-CVD, noncancer mortality, HR 1.45. In fact, any AMD was associated with all-cause, HR 1.42 and CVD, HR 1.45 mortality in women 80 and older.

“AMD is a predictor of poorer survival in women, especially those aged 80 and older,” study authors note. “Determination of shared risk factors may identify novel pathways for intervention that may reduce the risk of both conditions.”

1 Pedula KL, Coleman AL, Yu F, Cauley JA, Ensrud KE, Hochberg MC, Fink HA, Hillier TA; Study of Osteoporotic Fractures Research Group. Age-related macular degeneration and mortality in older women: the study of osteoporotic fractures. J Am Geriatr Soc. 2015 May;63(5):910-7. doi: 10.1111/jgs.13405. Epub 2015 May 4. PubMed PMID: 25941039; PubMed Central PMCID: PMC4439266.


Related Articles

Despite Overall Longevity Trends, Mortality Increases for Schizophrenia Patients

Since the 1970s, mortality rates have declined, extending average lifespan by almost a decade.

No Link Found Between H. Pylori Infection, Unexplained Anemia

Despite limited evidence to support the practice, testing for Helicobacter pylori (Hp) infection is recommended for work-up of unexplained iron deficiency anemia (IDA).


U.S. Medicine Recommends


More From department of veterans affairs

Department of Veterans Affairs (VA)

Fibromyalgia Presents Differently in Male, Female Veterans

Research on fibromyalgia, a poorly understood, chronically disabling pain syndrome, generally has focused on its clinical presentation and treatment.

Department of Veterans Affairs (VA)

How Veterans Feel About Remote Management of Their Care

The VA is expanding remote management of patients to improve disease prevention and care.

Department of Veterans Affairs (VA)

Stick-on Monitors Help Warn of Heart Failure Exacerbation in VA Study

While implantable devices have shown promise in reducing rehospitalization for heart failure (HF), VA researchers sought to determine if options that are less expensive and non-invasive would have comparable results.

Department of Veterans Affairs (VA)

Legislation: Clinicians Must Be Involved in Formulary Design, Purchasing

Legislation to prevent VA from outsourcing creation of its drug formulary and to require more input from medical professions is being considered in Congress.

Department of Veterans Affairs (VA)

GAO: VA Needs Better Planning for ‘Complex’ Appeals System Overhaul

SYRACUSE, NY — Despite limited evidence to support the practice, testing for Helicobacter pylori (Hp) infection is recommended for work-up of unexplained iron deficiency anemia (IDA). A study published in the journal Gastroenterology Report sought... View Article

Facebook Comment

Subscribe to U.S. Medicine Print Magazine

U.S. Medicine is mailed free each month to physicians, pharmacists, nurse practitioners, physician assistants and administrators working for Veterans Affairs, Department of Defense and U.S. Public Health Service.

Subscribe Now

Receive Our Email Newsletter

Stay informed about federal medical news, clinical updates and reports on government topics for the federal healthcare professional.

Sign Up