2017 Issues   /   Other

Lymphoma, Other Cancers Linked to HCV

By U.S. Medicine

HOUSTON — Hepatitis C virus (HCV) infection is known to cause hepatocellular carcinoma (HCC) and subtypes of non-Hodgkin lymphoma (NHL).

A report published in the journal Cancer sought to determine associations between HCV and other cancers in the U.S. elderly population. The study was conducted using Medicare claims by a research team including participation from the Michael E. DeBakey VAMC in Houston.1

Results indicate that prevalence of HCV, which was higher in cases than in controls at 0.7% vs 0.5%, was positively associated with the following cancers:

  • liver, with an adjusted odds ratio (aOR) pf 31.5,
  • intrahepatic bile duct (aOR, 3.40),
  • extrahepatic bile duct (aOR, 1.90),
  • pancreas (aOR, 1.23),
  • anus (aOR, 1.97)
  • nonmelanoma nonepithelial skin cancer (aOR, 1.53),
  • myelodysplastic syndrome (aOR, 1.56), and
  • diffuse large B-celllymphoma (aOR, 1.57).

Specific skin cancers found to be associated with HCV were Merkel cell carcinoma (aOR, 1.92) and appendageal skin cancers (aOR, 2.02).

Inverse associations were observed, however, with uterine cancer (aOR, 0.64) and prostate cancer (aOR, 0.73).

“HCV is associated with increased risk of cancers other than HCC in the US elderly population, notably bile duct cancers and diffuse large B-cell lymphoma,” study authors concluded. “These results support a possible etiologic role for HCV in an expanded group of cancers.”

  1. Mahale P, Torres HA, Kramer JR, Hwang LY, Li R, Brown EL, Engels EA. Hepatitis C virus infection and the risk of cancer among elderly US adults: A registry-based case-control study. Cancer. 2017 Apr 1;123(7):1202-1211. doi: 10.1002/cncr.30559. Epub 2017 Jan 24. PubMed PMID: 28117886.

Related Articles

Shulkin Ousted, White House Physician Nominated for VA Secretary

WASHINGTON — After several weeks of speculation regarding his future in the Trump Administration, VA Secretary David Shulkin, MD’s tenure came to an abrupt end on March 28.

Congress Seeks More Oversight of VA EHR Program

WASHINGTON — Legislation under consideration by Congress would increase oversight of VA’s adoption and implementation of its forthcoming electronic health record (EHR) system. The VA announced last year that it would adopt the same Cerner... View Article


U.S. Medicine Recommends


More From department of veterans affairs

Department of Veterans Affairs (VA)

Shulkin Ousted, White House Physician Nominated for VA Secretary

WASHINGTON — After several weeks of speculation regarding his future in the Trump Administration, VA Secretary David Shulkin, MD’s tenure came to an abrupt end on March 28.

Department of Veterans Affairs (VA)

Congress Seeks More Oversight of VA EHR Program

BRONX, NY — For patients with chronic kidney disease (CKD), living more than 30 miles from their nephrologist is associated with many unfavorable outcomes. They have lower rates of clinic visit adherence, more limited access... View Article

Department of Veterans Affairs (VA)

Congress, VSOs Have Wait-and- See Position on Jackson Nomination

BRONX, NY — For patients with chronic kidney disease (CKD), living more than 30 miles from their nephrologist is associated with many unfavorable outcomes. They have lower rates of clinic visit adherence, more limited access... View Article

Department of Veterans Affairs (VA)

VA Vows to Meet Deadline for Revamp of Veteran Claims Appeal Process

BRONX, NY — For patients with chronic kidney disease (CKD), living more than 30 miles from their nephrologist is associated with many unfavorable outcomes. They have lower rates of clinic visit adherence, more limited access... View Article

Department of Veterans Affairs (VA)

Vets With Respiratory Disease More Responsive to ‘Quit’ Programs

BRONX, NY — For patients with chronic kidney disease (CKD), living more than 30 miles from their nephrologist is associated with many unfavorable outcomes. They have lower rates of clinic visit adherence, more limited access... View Article

Facebook Comment

Subscribe to U.S. Medicine Print Magazine

U.S. Medicine is mailed free each month to physicians, pharmacists, nurse practitioners, physician assistants and administrators working for Veterans Affairs, Department of Defense and U.S. Public Health Service.

Subscribe Now

Receive Our Email Newsletter

Stay informed about federal medical news, clinical updates and reports on government topics for the federal healthcare professional.

Sign Up