<--GAT-->

Paliperidone Palmitate Helps Some Schizophrenia Patients

by U.S. Medicine

October 16, 2017

WHITE RIVER JUNCTION, VT — Even though nearly half of all patients diagnosed with schizophrenia have a history of substance abuse (SA), data on treatment of schizophrenia with paliperidone palmitate (PP) among patients with comorbid SA have been limited.

A study published in the journal Clinical Therapeutics compared all-cause and SA-related healthcare resource utilization and costs in veterans with schizophrenia and co-occurring SA who were treated with PP vs.oral atypical antipsychotics (OAAs).1

A team including researchers from the White River Junction, VT, VAMC employed VHA electronic health record data to conduct a retrospective longitudinal study in veterans with schizophrenia who initiated PP or OAA between Jan. 1, 2010, and June 30, 2016. Participants had more than 12 months of enrollment before treatment initiation (baseline), were diagnosed with SA, and had one or fewer Global Assessment of Functioning score during baseline.

Researchers estimated adjusted cost differences and incidence rate ratios (IRR) for the association between PP vs. OAA and all-cause and SA-related healthcare costs and healthcare resource utilization in the 12 months after treatment initiation.

Results indicated that, of 6,872 veterans in the study, 1,684 (25%) and 5,188 (75%) were treated with PP and OAA, respectively.

After adjustment, PP was associated with fewer all-cause inpatient (IRR = 0.88), mental health-related inpatient (IRR = 0.88) and long-term care stays (IRR = 0.53) compared with OAA. It was associated with more frequent mental health intensive case management visits (IRR = 1.51), however.

At the same time, PP was associated with significantly lower rates of SA-related inpatient stays (IRR = 0.80), mental health stays (IRR = 0.85) long-term care stays (IRR = 0.22) and outpatient visits (IRR = 0.78) than OAA, study authors reported.

Treatment with PP also saved money compared to OAA, the report noted. Patients treated with PP also had lower mean annual all-cause $10,473 lower cost, and SA-related, $8,457 lower cost.

 “PP was associated with significant total medical cost savings resulting from fewer hospitalizations and lower rates of SA-related health care resource utilization compared with OAA in patients with schizophrenia and comorbid SA,” study authors concluded. “Thus, PP appears to be a valuable treatment option for patients in this subpopulation.”

1. Lefebvre P, Muser E, Joshi K, DerSarkissian M, Bhak RH, Duh MS, Shiner B,Young-Xu Y. Impact of Paliperidone Palmitate Versus Oral Atypical Antipsychotics on Health Care Resource Use and Costs in Veterans With Schizophrenia and ComorbidSubstance Abuse. Clin Ther. 2017 Jul;39(7):1380-1395.e4. doi:10.1016/j.clinthera.2017.05.356. Epub 2017 Jun 20. PubMed PMID: 28641996.


Comments are closed here.


Related Articles

VA Struggles to Overcome Women’s Healthcare Disparities

WASHINGTON—VA is straining its capacity and struggling against a culture that can sometimes be hostile to women as it responds to what VA officials consider a “tsunami wave of women veterans” over the last decade.... View Article

VA Researcher Seeks to Include Veterans’ Voices in Healthcare Decisions

SEATTLE—It’s a big job to ensure that VA’s healthcare system is equipped to provide the best possible care to veterans. It might be an even bigger job to make sure that veterans across the country... View Article


U.S. Medicine Recommends


More From department of veterans affairs

Department of Veterans Affairs (VA)

VA Struggles to Overcome Women’s Healthcare Disparities

WASHINGTON—VA is straining its capacity and struggling against a culture that can sometimes be hostile to women as it responds to what VA officials consider a “tsunami wave of women veterans” over the last decade.... View Article

Department of Veterans Affairs (VA)

VA Researcher Seeks to Include Veterans’ Voices in Healthcare Decisions

WASHINGTON—VA is straining its capacity and struggling against a culture that can sometimes be hostile to women as it responds to what VA officials consider a “tsunami wave of women veterans” over the last decade.... View Article

Department of Veterans Affairs (VA)

House Committee Looks at Influence Trump Friends Have Had on VA

WASHINGTON—VA is straining its capacity and struggling against a culture that can sometimes be hostile to women as it responds to what VA officials consider a “tsunami wave of women veterans” over the last decade.... View Article

Department of Veterans Affairs (VA)

VA Announces Proposed Standards for Access to Mission Act Outside Care

WASHINGTON—VA is straining its capacity and struggling against a culture that can sometimes be hostile to women as it responds to what VA officials consider a “tsunami wave of women veterans” over the last decade.... View Article

Department of Veterans Affairs (VA)

VA Announces New Partnerships to Expand Telehealth Services

WASHINGTON—VA is straining its capacity and struggling against a culture that can sometimes be hostile to women as it responds to what VA officials consider a “tsunami wave of women veterans” over the last decade.... View Article

Subscribe to U.S. Medicine Print Magazine

U.S. Medicine is mailed free each month to physicians, pharmacists, nurse practitioners, physician assistants and administrators working for Veterans Affairs, Department of Defense and U.S. Public Health Service.

Subscribe Now

Receive Our Email Newsletter

Stay informed about federal medical news, clinical updates and reports on government topics for the federal healthcare professional.

Sign Up