Recent Endocrinology Studies

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Endocrine Studies in Health and Disease

Objective: This study will evaluate healthy normal volunteers and patients with a variety of endocrine disorders to 1) learn more about conditions that affect the endocrine glands (glands that secrete hormones) and 2) train physicians in endocrinology. All participants will have a physical examination medical and history. They may be required to provide blood, saliva, or urine samples and undergo ultrasound (using sound waves) or magnetic resonance (using a magnetic field) imaging to visualize internal body structures. Some healthy adult volunteers will have hormone-stimulating tests to assess endocrine function. These tests measure blood hormone levels before and after injection of a synthetic form of a hormone. A device called a heparin lock, through which the hormone is injected and the blood samples are collected, is placed in a vein in the arm or hand. Blood samples are drawn before the hormone is injected and at various intervals after the injection to measure levels of the hormone.

Sponsor: NIH Clinical Center

Contact: Patient Recruitment and Public Liaison Office, (800) 411-1222, prpl@mail.cc.nih.gov

Status: Currently recruiting

Clinical Trials Identifier: NCT00006073

Functional and Physiological Responses to Lokomat® Therapy

Objective: Individuals with neurological deficiencies such as those who have spinal cord injury, stroke, traumatic brain injury, Parkinson’s disease, and multiple sclerosis often lose their ability to ambulate over ground. Loss of functional mobility not only impedes everyday life, but may also affect many systems and organs in the body. The investigators are interested in obtaining a wide variety of data in order to obtain a better understanding of changes that occur as a result of receiving Lokomat therapy. The investigators will be studying body composition, cardiac, pulmonary, endocrine, metabolic, and molecular changes after a 12-week clinical therapy program.

Sponsor: VA

Contact: Contact: Pierre K Asselin, (718)584-9000 ext 3124, Pierre.Asselin@va.gov

Status: Currently recruiting

Clinical Trials Identifier: NCT00883142

Impact of Accu-Chek 360® in Veterans with Type 2 Diabetes

Objective: To show that a structured treatment plan based upon Accu-Chek 360 View has a favorable effect on physician decision-making and HbA1c for patients on oral hypoglycemic agents (OHA) or insulin for Type 2 diabetes (T2D). Hypothesis 1: Compared to controls, intervention subjects will undergo a greater number of medication changes and have a lower HbA1 at the conclusion of the study. Hypothesis 2: Higher rates of monitoring at entry will be associated with lower CHO consumption, lower percent body fat, higher medication compliance, and higher physical activity levels. Hypothesis 3: Patients with lower rates of monitoring at entry will have higher rates of depression, be more likely to have an external locus of control, and express greater fear about self-testing.

Sponsor: VA

Contact: Glen H Murata, MD, New Mexico VA Health Care System

Status: Currently recruiting

Clinical Trials Identifier: NCT00824694

Exercise-facilitated Neuro-rehabilitation in Diabetic Neuropathy

Objective: This study will determine the type and combination of exercise needed to rehabilitate the neuro-compromised diabetic veteran. Guided exercise protocols may prove to be practical therapeutic options for the prophylactic management of diabetic subjects with neuropathy.

Sponsor: VA

Contact: Mazy Miller, RN, (708)202-4171, mazy.miller@va.gov

Status: Currently recruiting

Clinical Trials Identifier: NCT00955201

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