Why Opioids Are Discontinued in VHA Patients

PORTLAND, OR — Discontinuation of opioids can be accelerated for several reasons, according to a new study, including lack of information about the long-term effectiveness of opioids for chronic pain, heightened awareness about opioid-related adverse events, closer monitoring of patients for opioid-related aberrant behaviors, and greater restrictions around opioid prescribing.

That’s especially the case in patients considered “high risk,” noted the article published recently in the journal Pain.1

The study led by researchers from the Center to Improve Veteran Involvement in Care at the VA Portland, OR, Healthcare System sought to compare reasons for discontinuation of long-term opioid therapy (LTOT) between patients with and without substance use disorder (SUD) diagnoses receiving care within the VHA.

The retrospective cohort study involved a cohort of veteran patients prescribed opioid therapy for at least 12 consecutive months who subsequently discontinued opioid therapy for at least 12 months. From the cohort, researchers randomly selected 300 patients with SUD diagnoses and propensity score-matched 300 patients without SUD diagnoses.

Used to determine reasons for LTOT discontinuation was a comprehensive manual review of patients’ medical records. Results indicated that most patients (85%) were discontinued because of clinician, rather than patient, decisions.

For patients whose clinicians initiated discontinuation, 75% were discontinued because of opioid-related aberrant behaviors. Compared to patients without SUD diagnoses, those with SUD diagnoses were more likely to discontinue LTOT because of aberrant behaviors — 81% vs. 68% — usually abuse of alcohol or other substances.

“This is the first study to document reasons for discontinuation of LTOT in a sample of patients with and without SUD diagnoses,” study authors wrote. “Treatments that concurrently address SUD and chronic pain are needed for this high-risk population.”

  1. Lovejoy TI, Morasco BJ, Demidenko MI, Meath TH, Frank JW, Dobscha SK. Reasons for discontinuation of long-term opioid therapy in patients with and without substance use disorders. Pain. 2017 Mar;158(3):526-534. doi: 10.1097/j.pain.0000000000000796. PubMed PMID: 28192376.

Comments (3)

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  1. Wayne Hachey says:

    While it is reassuring that great efforts are being made to counter opioid misuse many veterans are then subject to substandard care and ineffective pain management. The study cited above includes some 25% of the study population without aberrant behaviors in whom their provider discontinued pain medications. The same diligence should be applied to address appropriate and effective pain management rather than often draconian measures targeting meeting a goal of decreased opioid use.

  2. Micha Smith-Hammond says:

    This article about “reasons for discontinuation” is not very informative and raises more questions than answers about the actual patients that suffer from chronic pain. In no way can a clinician apply this article to their practice.

    Questions to think about:
    1. So, are these patients still in pain?
    2. Were they switched to another non-opioid med?
    3. Are the patients satisfied with their care?
    4. Are they now receiving proper pain management?
    5. Without the opioids for pain are these patients with SUD turning to more harmful substances?
    6. Did benefits outweigh the risks of stopping opioid with this diagnosis?
    7. What was the timeframe for follow-up after stopping opioid therapy?
    8. Was mental health evaluated properly in this population?
    9. What was the patient’s severity of pain after stopping opioid treatment?

  3. M Jarrett says:

    This is totally laughable !!! It is blatantly obvious these days that when those that are in charge, from the President down to the pharmacist want the opioids to go away unless the patient has cancer they will go away !!!

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