HCV Eradication Lowers Glucose Levels in Veterans With Diabetes

by U.S. Medicine

December 15, 2017

PORTLAND, OR—Hepatitis C virus (HCV) infection is linked to diabetes and often worsens glycemic control in patients with diabetes.

A study published in Diabetes Care investigated whether eradication of HCV infection with direct-acting antiviral (DAAs) agents is associated with improved glycemic control in patients with diabetes.1

VA researchers from Portland, OR, and Seattle identified 2,435 patients with diabetes who underwent interferon-free and ribavirin-free DAA-based antiviral treatment for HCV in the national VA healthcare system. They tracked changes in average hemoglobin A1c (HbA1c) level and use of antidiabetic medications one year before and after antiviral treatment between patients who achieved sustained virologic response (SVR) and those who did not.

Results indicated that, among patients with elevated baseline HbA1c, the drop in HbA1c associated with antiviral treatment was greater in those who achieved SVR (0.98%) than in those with treatment failure (0.65%) for an adjusted mean difference of 0.34.

In addition, use of antidiabetic medications decreased more in patients who achieved SVR than in those who sustained treatment failure, especially for the use of insulin, which dropped significantly from 41.3% to 38% in patients achieving SVR compared with a slight increase from 49.8% to 51% in those who had treatment failure.

“DAA-based eradication of HCV is associated with improved glycemic control in patients with diabetes as evidenced by decreased mean HbA1c and decreased insulin use,” study authors concluded. “These endocrine benefits of SVR provide additional justification for considering antiviral treatment in all patients with diabetes.”

  1. Hum J, Jou JH, Green PK, Berry K, Lundblad J, Hettinger BD, Chang M, Ioannou GN. Improvement in Glycemic Control of Type 2 Diabetes After Successful Treatment of Hepatitis C Virus. Diabetes Care. 2017 Sep;40(9):1173-1180. doi: 10.2337/dc17-0485. Epub 2017 Jun 28. PubMed PMID: 28659309.

Comments are closed here.


Related Articles

Current Treatment Halves Cardiovascular Disease Risk in Hep C Patients

PITTSBURGH—In more good news for veterans who have received treatment for hepatitis C virus, VA researchers have found that treatment not only reduces the risk of complications from liver disease, it also dramatically reduces the... View Article

VA Models Allow Earlier Identification of HCV Patients at Risk of Progression

ANN ARBOR, MI—New prognostic models developed by VA researchers can help clinicians identify which patients who have or have had chronic hepatitis C virus infection will develop cirrhosis or hepatocellular carcinoma. While the VA has... View Article


U.S. Medicine Recommends


More From hepatitis

Cardiovascular Disease

Current Treatment Halves Cardiovascular Disease Risk in Hep C Patients

PITTSBURGH—In more good news for veterans who have received treatment for hepatitis C virus, VA researchers have found that treatment not only reduces the risk of complications from liver disease, it also dramatically reduces the... View Article

Hepatitis

VA Models Allow Earlier Identification of HCV Patients at Risk of Progression

ANN ARBOR, MI—New prognostic models developed by VA researchers can help clinicians identify which patients who have or have had chronic hepatitis C virus infection will develop cirrhosis or hepatocellular carcinoma. While the VA has... View Article

Hepatitis

Hepatitis C Declines Among Active Military; Highest Rates for Baby Boomers

New cases of acute and chronic hepatitis C (HCV) have dropped sharply among U.S. servicemembers since 2008, bucking the nationwide trend.

Hepatitis

HCV Complications Rise in Women Veterans While Beginning Decline in Men

VA researchers expect complications from chronic hepatitis C virus (HCV) in women veterans to continue to rise for a decade or longer after rates begin to decline in men.

Hepatitis

HCV Complications Increasing for Women Veterans

HOUSTON—The epidemiology clinical course of hepatitis C virus (HCV) infection is affected by gender. Yet, few long-term longitudinal studies have examined trends in the incidence and prevalence of serious liver complications among women compared with... View Article

Subscribe to U.S. Medicine Print Magazine

U.S. Medicine is mailed free each month to physicians, pharmacists, nurse practitioners, physician assistants and administrators working for Veterans Affairs, Department of Defense and U.S. Public Health Service.

Subscribe Now

Receive Our Email Newsletter

Stay informed about federal medical news, clinical updates and reports on government topics for the federal healthcare professional.

Sign Up