<--GAT-->
Clinical Topics

Melanomas Associated With Internal Malignancy Risk

by U.S. Medicine

January 1, 2019

PALO ALTO, CA — Genetic and environmental risk factors have been associated with the development of multiple primary melanomas (MPM) but a new study questioned whether those patients might have increased predisposition to developing internal malignancies.

The report published in the Journal of the American Academy of Dermatology sought to identify the risk of subsequent malignancies in MPM patients.1

Researchers from the VA Palo Alto, CA, Health Care System and Stanford University Medical Center analyzed multiple primary standardized incidence ratios for patients with one or more, two or more and three or more primary melanomas (PM) in the SEER database from 1973-2014.

Ultimately, they identified 223,799 patients with one or more, 19,709 with two or more and 3,995 with three or more PM, and found that risks of subsequent internal malignancy increased with number of PM, with observed to expected (O/E) ratios of 0.99, 1.14, and 1.23 (p<0.05) for patients with at least one, two and three PM respectively.

The study team reported that Internal malignancy was higher in younger MPM patients and those with superficial spreading melanoma

Most frequent malignancies among MPM patients included breast, prostate, thyroid, soft tissue, brain, kidney, non-Hodgkin’s lymphoma, and chronic lymphocytic leukemia. Results indicated that risk of subsequent cutaneous melanoma increased with O/E ratios of 8.09, to 22.52, to 41.03 (p<0.05) respectively.

While limited by incomplete SEER information about pigmentation phenotypes, histology, and treatments, study authors concluded, “Patients with MPM have increased risk of subsequent internal and cutaneous malignancies and may benefit from tight adherence to age-specific cancer screening.”

1. Cai ED, Swetter SM, Sarin KY. Association of multiple primary melanomas with malignancy risk: a population-based analysis of the Surveillance, Epidemiology, and End Results Program database from 1973-2014. J Am Acad Dermatol. 2018 Oct 1. pii: S0190-9622(18)32637-9. doi: 10.1016/j.jaad.2018.09.027. [Epub ahead of print] PubMed PMID: 30287320.



Related Articles

HIV Patients Had Lower PC Incidence in VA Study

NEW YORK—Non-AIDS defining cancers are increasingly important contributors to health outcomes for aging persons with HIV (PWH), according to a recent conference presentation which also pointed out that, although prostate cancer is prevalent in aging... View Article

VA Study Finds No Link Between ADT, Dementia

LA JOLLA, CA—Research has been conflicting on whether androgen deprivation therapy is related to dementia. A research letter in JAMA Oncology pointed out that two studies reported a strong statistically significant association between ADT and... View Article


U.S. Medicine Recommends


More From oncology

Oncology

Overcoming Radiation Resistant Prostate Cancer

A new study looks at factors to improve survival rates in veterans with multiple sclerosis. VA’s efforts don’t stop there, however. The healthcare system has a multipronged effort to reduce disability and improve quality of... View Article

Oncology

JAK Enzymes Can Treat Leukemia, Lymphoma

A new study looks at factors to improve survival rates in veterans with multiple sclerosis. VA’s efforts don’t stop there, however. The healthcare system has a multipronged effort to reduce disability and improve quality of... View Article

Oncology

Response of Veterans to PD-1 Checkpoint Inhibitors

A new study looks at factors to improve survival rates in veterans with multiple sclerosis. VA’s efforts don’t stop there, however. The healthcare system has a multipronged effort to reduce disability and improve quality of... View Article

Oncology

Surgical Staging Often Inadequate for Gallbladder Cancer

Guidelines frequently aren’t followed when it comes to radical cholecystectomy with regional lymphadenectomy for patients with T1b gallbladder cancer.

Oncology

Use of Hospice During Treatment Has Limited VA Use

Unlike in most private sector settings, veterans with advanced cancer can receive hospice care concurrently with treatments such as radiation and chemotherapy.

Subscribe to U.S. Medicine Print Magazine

U.S. Medicine is mailed free each month to physicians, pharmacists, nurse practitioners, physician assistants and administrators working for Veterans Affairs, Department of Defense and U.S. Public Health Service.

Subscribe Now

Receive Our Email Newsletter

Stay informed about federal medical news, clinical updates and reports on government topics for the federal healthcare professional.

Sign Up