Recent Oncology Studies November 2010

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Studying Genes, Environment, and Prostate Cancer Risk

Objective: The study has four objectives: to evaluate the evidence of familial aggregation for prostate cancer and identify a homogenous subgroup of families with elevated likelihood of aggressive disease using a family case-control design; to determine if genetic variation in selected genes involved in reactive oxygen species detoxification and the oxidative stress response are independently or jointly associated with greater mitochondrial DNA damage and increased prostate cancer risk; to determine if dietary intake of ω-3 fatty acids alters the risk of prostate cancer; and to determine the association between variation in genes involved in ROS detoxification, oxidative stress response, and prostate cancer risk.

Sponsor: VA

Contact: Jackilen Shannon, PhD, Portland VAMC, shannoja@ohsu.edu

Status: Recruiting

Skin Cancer Prevention

Objective: To see if 5-fluorouracil (5-FU) skin cream can prevent the growth of new skin cancers on the face and ears. The cost of trying to prevent skin cancer will be compared to the usual cost of treating skin cancer. Patients recruited in the study will have been treated for two or more skin cancers within the past five years, with at least one having been on their face or ears.

Sponsor: VA

Contact: Patricia Baldwin, RN, patricia.baldwin@va.gov

Status: Recruiting

Combination Targeted Radiotherapy in Neuroendocrine Tumors

Objective: To determine what fraction of individuals with neuroendocrine tumors would show improved tumor dosimetry with combined agent therapy compared to “best” single agent therapy and determine the magnitude of the potential tumor radiation dose increase. Researchers plan to perform serial scintigraphic imaging procedures to measure patient specific bone marrow, kidney, and tumor biodistribution and kinetics for 111In pentetreotide and 131I-MIBG in adults and children with neuroendocrine tumors. Using the program already developed, they will input the individual dosimetry measures for bone marrow, kidney, and tumor to determine the optimal amounts of administered radioactivity for the combination of 131I MIBG plus 90Y DOTATOC or 131I MIBG alone.

Sponsor: VA

Contact: Dr David Bushnell, Iowa City VAMC

Status: Recruiting by invitation only

Cap Assisted Colonoscopy for the Detection of Colon Polyps

Objective: The investigators hypothesize that adenoma detection rate will be higher using cap assisted colonoscopy compared to standard colonoscopy. Also, cap assisted colonoscopy will be safe
and cecal intubation rate will be similar compared to standard colonoscopy. The study will: compare the prevalence of adenomas detected by standard colonoscopy and cap assisted colonoscopy; compare the number of adenomas detected per subject by standard colonoscopy and cap assisted colonoscopy; and compare the cecal intubation rate, insertion time, withdrawal time, and complications of standard colonoscopy and cap assisted colonoscopy.

Sponsor: American Society for Gastrointestinal Endoscopy (with data provided by Kansas City VAMC)

Contact: Deepthi Rao, deepthi.rao@va.gov

Status: Recruiting

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