b'ANJESO (meloxicam) injection CONTRAINDICATIONS:ANJESO (meloxicam) Injection Rx only Contraindicated in patients with known history of hypersensitivity to meloxicam or any components of the BRIEF SUMMARY: This information is notdrug product. Contraindicated in patients with a history comprehensive. Visit www.anjeso.com to obtain theof asthma, urticaria, or other allergic-type reactions after FDA-approved product labeling or call 1-844-303-5510. taking aspirin or other NSAIDs. Contraindicated in patients in the setting of coronary artery bypass graft (CABG) WARNING: RISK OF SERIOUS CARDIOVASCULAR AND surgery. Contraindicated in patients with moderate to GASTROINTESTINAL EVENTS severe renal insufficiency who are at risk for renal failure Cardiovascular Riskdue to volume depletion.Non-steroidal anti-inflammatory drugsWARNINGS AND PRECAUTIONS:(NSAIDs) cause an increased risk of seriousHepatotoxicityInform patients of warning signs and cardiovascular thrombotic events includingsymptoms of hepatotoxicity and discontinue ANJESO myocardial infarction and stroke, which can beimmediately if abnormal liver tests persist or worsen or if fatal. This risk may occur early in treatment andclinical signs and symptoms of liver disease develop.may increase with duration of use.ANJESO is contraindicated in the setting ofHypertensionPatients taking some antihypertensive coronary artery bypass graft (CABG) surgery.medications may have impaired response to these therapies while taking ANJESO, monitor patients blood pressure.Gastrointestinal RiskHeart Failure and EdemaAvoid use of ANJESO in NSAIDs cause an increased risk of seriouspatients with severe heart failure unless benefits are gastrointestinal (GI) adverse events includingexpected to outweigh risks of worsening heart failurebleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. TheseRenal ToxicityMonitor renal function in patients with events can occur at any time during use andrenal or hepatic impairment, heart failure, dehydration without warning symptoms. Elderly patientsor hypovolemia. Avoid use of ANJESO in patients with and patients with a prior history of peptic ulceradvanced renal disease unless benefits are expected to disease and/or GI bleeding are at greater risk foroutweigh risk of worsening renal functionserious GI events. Anaphylactic ReactionsSeek emergency help if an For more details about Cardiovascular andanaphylactic reaction occurs.Gastrointestinal Risks please see the product label Exacerbation of Asthma Related to Aspirin INDICATIONS AND USAGE: Sensitivity ANJESO is contraindicated in patients with aspirin-sensitive asthma. Monitor patients with preexisting ANJESO is an NSAID indicated for use in adults for theasthma.management of moderate-to-severe pain, alone or inPregnancy and LactationWomen in the third trimester combination with non-NSAID analgesics. of their pregnancies or who are breast feeding should avoid LIMITATION OF USE: use of ANJESO.Because of delayed onset of analgesia, ANJESO alone isADVERSE REACTIONS:not recommended for use when rapid onset of analgesiaThe most common adverse reactions occurring in clinical is required. trials at a rate2% and greater in ANJESO than placebo treated patients, include: constipation, elevated levels of blood gamma-glutamyltransferase, and anemia. For additional information on these and other adverse reactions please see details in the label.20-MCAM-0071_b_Branded_JrnlAd_TheCompendium_DR2.indd 2 5/11/20 2:03 PM'