b'The following adverse reactions have been identified duringManage patients with symptomatic and supportive care post approval use of the oral formulation of meloxicam.following an NSAID overdosage. There are no specific Since these reactions are reported voluntarily from aantidotes. Forced diuresis, alkalinization of urine, population of uncertain size, it is not always possible tohemodialysis, or hemoperfusion may be employed but are reliably estimate their frequency or establish a causalnot likely to be useful due to high protein binding.relationship to drug exposure. There is limited experience with meloxicam overdose. In Adverse reactions reported in worldwide post marketingfour reported cases of meloxicam overdose, patients took experience or the literature include: acute urinary6 to 11 times the highest available oral dose of meloxicam retention; agranulocytosis; alterations in mood (such astablets (15 mg); all recovered. Cholestyramine is known mood elevation); anaphylactoid reactions including shock;to accelerate the clearance of meloxicam. Accelerated erythema multiforme; exfoliative dermatitis; interstitialremoval of meloxicam by 4 g doses of cholestyramine nephritis; jaundice; liver failure; Stevens-Johnsongiven three times a day was demonstrated in a clinical trial. syndrome; toxic epidermal necrolysis, and infertility female.Administration of cholestyramine may be useful following For additional information please see details in the label. an overdosage. In case of an overdosage, discontinue DRUG INTERACTIONS: ANJESO therapy and contact a regional poison control center at 1-800-222-1222.Patients taking drugs that Interfere with Hemostasis (e.g., warfarin, aspirin, SSRIs/SNRIs) should be monitored for This information is not comprehensivebleeding while they are taking ANJESO. Concomitant use How to get more information:of ANJESO and analgesic doses of aspirin is not generally Talk to your healthcare providerrecommended.Visit www.anjeso.com to obtain the FDA-approved Concomitant use of ANJESO in patients taking ACE Inhibitors,product labelingAngiotensin Receptor Blockers (ARBs), or Beta-Blockers may Call 1-844-303-5510have a diminished antihypertensive effect of these drugs.This brief summary is based on ANJESO prescribing These patients should have their blood pressure monitored. information revised February 2020.Concomitant use of ANJESO in patients taking ACE Inhibitors and ARBs with additional risk factors such as the0220-004.a Copyright2020 Baudax Bio.elderly, volume-depleted, or those with renal impairmentAll rights reserved. may result in deterioration of renal function. In such highBaudax Bio and ANJESO are registered trademarks of risk patients, monitor for signs of worsening renal function. Baudax Bio Inc.NSAIDs such as ANJESO can reduce the natriuretic effect of diuretics such as furosemide and thiazide diuretics.Rx OnlyMonitor these patients to assure diuretic efficacy including antihypertensive effects. Manufactured and marketed by:OVERDOSAGE:Symptoms following acute NSAID overdoses have been typically limited to lethargy, drowsiness, nausea, vomiting,Baudax Bio and epigastric pain, which have been generally reversible490 Lapp Road with supportive care. Gastrointestinal bleeding hasMalvern, PA 19355occurred. Hypertension, acute renal failure, respiratory depression and coma have occurred, but were rare.20-MCAM-0071_b_Branded_JrnlAd_TheCompendium_DR2.indd 3 5/11/20 2:03 PM'