b'Hepatitis C Cure Doesnt Always Prevent Hepatocellular Carcinoma Development Source: Dash S, Aydin Y, Widmer KE, Nayak L. Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment. J Hepatocell Carcinoma. 2020;7:45-76. Published 2020 Apr 15. doi:10.2147/JHC.S221187https://pubmed.ncbi.nlm.nih.gov/32346535/by which HCV contributes to the de- means,achievementofasustainedthelong-termhealingofcirrhotic velopment of the cancer as well as thevirologicresponseleadstoregres- patientsafterHCVcure,theysaid. interplay of a number of other factorssionofcirrhosisinnearly55%ofThese patients need to remain under that increase the risk of HCC. patients,theysaid.Thatreducessurveillanceforlivercomplications, A team of researchers led by Srikantatheir risk of HCC. including HCC.Dash, PhD, of the Southeast LouisianaOntheflipside,patientswhohave1Ioannou GN, Beste LA, Green PK, et al. VeteransHealthCareSystem,andachieved SVR remain at risk for liverIncreased Risk for Hepatocellular Carcinoma directoroftheHepatitisResearchdiseaseprogressionduetonon-viralPersists Up to 10 Years After HCV Eradica-Laboratory and professor of Pathologyrisk factors including obesity, alcohol,tion in Patients With Baseline Cirrhosis or attheTulaneUniversitySchoolofdiabetes,andotherautoimmunedis- High FIB-4 Scores. Gastroenterology. Medicine,bothinNewOrleans,eases, they noted.2019;157(5):1264-1278.e4. doi:10.1053/j.explored the impact of multiple factorsCloselyassociatedwiththosefac- 2 gastro.2019.07.033on the development of HCC followingtors in the risk in non-alcoholic fatty Dash S, Aydin Y, Widmer KE, Nayak L. Hepa-tocellular Carcinoma Mechanisms Associated successful treatment for hepatitis C in aliver disease (NAFLD), now the mostwith Chronic HCV Infection and the Impact of recent review. 2 common chronic liver disease in theDirect-Acting Antiviral Treatment. J Hepato-Dash and his colleagues proposed thatworld.VeteranswithNAFLDhavecell Carcinoma. 2020;7:45-76. Published 2020 HCC mechanisms associated to HCV800% greater risk of HCC comparedApr 15. doi:10.2147/JHC.S221187infection can be direct virus-induced cel- to veterans without the disease, a large3Kanwal F, Kramer JR, Mapakshi S, Na-lular programming, indirect host-relatedstudy found. 3 tarajan Y, Chayanupatkul M, Richardson inflammatory response, and an overlap- That increased risk drives home thePA, Li L, Desiderio R, Thrift AP, Asch SM, ping host metabolic bystander effect. importanceofDashandcolleaguesChu J, El-Serag HB. Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty While the hepatitis C virus directlyrecommendation. Liver Disease. Gastroenterology. 2 Dec damagestheliverthroughmultipleFatty liver is a particular threat to2018;155(6):1828-1837.e2.682020 COMPENDIUM OF FEDERAL MEDICINE'