Biomarkers Different in Acute HF Patients With, Without Diabetes

by U.S. Medicine

October 16, 2017

GRONINGEN, THE NETHERLANDS – How diabetes affects pathophysiological processes among patients with acute heart failure (AHF) is unclear, according to a new study published in the European Journal of Heart Failure.1

To add to that information, a study team led by the University of Groningen in The Netherlands and including participation from the San Francisco VAMC, analyzed a panel of 48 circulating biomarkers measured within 24 hours of admission for AHF in a subset of patients enrolled in the PROTECT trial. In patients with and without diabetes, the researchers performed a network analysis to identify correlations between measured biomarkers.

Results suggested that, compared with the 1,111 patients without diabetes, the 922 with diabetes had a higher prevalence of ischemic heart disease and traditional coronary risk factors. After multivariable adjustment, patients with and without diabetes had significantly different levels of biomarkers across a spectrum of pathophysiological domains, including inflammation (TNFR-1a, periostin), cardiomyocyte stretch (BNP), angiogenesis (VEGFR, angiogenin), and renal function (NGAL, KIM-1) (adjusted P-value <0.05).

Among patients with diabetes, network analysis revealed that periostin strongly clustered with C-reactive protein and interleukin-6. Renal markers (creatinine and NGAL) were found to be closely associated with potassium and glucose. Those findings were not seen among patients without diabetes, the researchers pointed out.

“Patients with AHF and diabetes, compared with those without diabetes, have distinct biomarker profiles,” study authors concluded. “Network analysis suggests that cardiac remodeling, inflammation, and fibrosis are closely associated with each other in patients with diabetes. Furthermore, potassium levels may be sensitive to changes in renal function as reflected by the strong renal-potassium-glucose correlation. These findings were not seen among patients without diabetes and may suggest distinct pathophysiological processes among AHF patients with diabetes.”

1. Sharma A, Demissei BG, Tromp J, Hillege HL, Cleland JG, O’Connor CM, Metra M, Ponikowski P, Telerik JR, Davison BA, Givers MM, Bloomfield DM, Dittrich H, van Veldhuisen DJ, Cotter G, Zeolite JA, Khan MAF, Boors AA. A network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure. Euro J Heart Fail. 2017 Jun 21. doi: 10.1002/ejhf.912. [Epub ahead of print] PubMed PMID: 28639369.


Comments are closed here.


Related Articles

Pharmacist Medication Management Helps Diabetic Veterans, Physicians

HINES, IL—Older age, obesity and Agent Orange exposure create a trifecta of diabetes risk for the VA. Nearly 25% of veterans have diabetes, making efficient and effective management of their care a top concern for... View Article

Seeing Combat Can Make Aging More Difficult for Veterans

PORTLAND, OR—Being exposed to combat makes a significant difference in how military veterans fare during aging, according to a new study, which also found that the experience increases the risk for depression and anxiety later... View Article


U.S. Medicine Recommends


More From department of veterans affairs

Department of Veterans Affairs (VA)

Seeing Combat Can Make Aging More Difficult for Veterans

PORTLAND, OR—Being exposed to combat makes a significant difference in how military veterans fare during aging, according to a new study, which also found that the experience increases the risk for depression and anxiety later... View Article

Department of Veterans Affairs (VA)

Top VISN 7 Officials Removed After Cancer Patient Attacked by Insects

Elderly AF Veteran Had More Than 100 Ant Bites Before Death ATLANTA—Nine VA employees, including the VISN 7 director and chief medical officer, have been reassigned following reports that an elderly patient at the Atlanta... View Article

Department of Veterans Affairs (VA)

Women, Chronically Ill Veterans Value Veterans Choice Access Most

HINES, IL—Women and veterans with multiple comorbidities used and valued the Veterans Choice Program (VCP) more than other veterans, according to recent research by the VA.1 To help these veterans and others, the VA has... View Article

Department of Veterans Affairs (VA)

VA Facing Critical Healthcare Staffing Shortages in Near Future

Replacing Retirees Hampered by Lower Salaries WASHINGTON—Oversight agencies are sounding the alarm that VA is plagued with large staffing shortages in critical areas, including physicians, registered nurses, physician assistants, psychologists and physical therapists, as well... View Article

Department of Veterans Affairs (VA)

Processes Similar in Schizophrenia, Psychotic Biopolar Disorder

NASHVILLE, TN—Processes leading to impairment in schizophrenia and psychotic bipolar disorder might be more similar than previously assumed, according to a new study. The report in Schizophrenia Research pointed out that neuropsychological impairment is common... View Article

Subscribe to U.S. Medicine Print Magazine

U.S. Medicine is mailed free each month to physicians, pharmacists, nurse practitioners, physician assistants and administrators working for Veterans Affairs, Department of Defense and U.S. Public Health Service.

Subscribe Now

Receive Our Email Newsletter

Stay informed about federal medical news, clinical updates and reports on government topics for the federal healthcare professional.

Sign Up