<--GAT-->

Study Determines Patients Most Vulnerable to E. Coli H30

by U.S. Medicine

July 6, 2016

MINNEAPOLIS—The pandemic strain of drug-resistant E. coli H30 begins as a subtle, hard-to-detect infection, usually of the urinary tract. The strain is of special concern, however, according to a report in Clinical Infectious Diseases, because it appears to have an intrinsic ability to cause persistent, harmful and, sometimes, deadly infections.1

Minneapolis VA Health Care System-led researchers pointed out that no other type of E. coli causes as much widespread damage worldwide because H30 can go unnoticed at first.

A particular genetic family of E. coli, Sequence Type 131, produced the H30 strain, which appeared during the late 1990s. It quickly expanded around the world to become the dominant drug-resistant strain in virtually all populations.

“No other type of E. coli is causing this much widespread damage,” said co-author Evgeni Sokurenko of the University of Washington in Seattle. “We need to pay as much attention to it as we do to the superbug MRSA, the treatment-resistant staph infection.”

Each year in the United States alone, H30 may cause more than 1 million urinary tract infections, as well as much more lethal blood infections, according to background information in the report.

For the study, researchers explored possible associations of H30 with patient characteristics, clinical manifestations, treatment and how well or poorly the patients fared. Results indicated that researchers found that individuals at greatest risk for E. coli H30 infection tended to be older women and men who had been in a healthcare facility, including long-term care residences or hospitals, who had received antibiotics and who had underlying conditions that weakened their ability to ward off infections.

Yet, at their first clinical visit, those patients were significantly less likely to be suspected of having an infection and less likely to receive a proper antibiotic prescription, according to the study, leading to a severe complication.

The researchers reported that H30 “was strongly associated with ineffective initial antimicrobial therapy, clinical and microbial persistence, and diverse, later-occurring adverse effects.”

“H30 might have that dangerous combination of being both highly resistant to antibiotics and highly successful as a stealth pathogen,” Sokurenko added. “This double-trouble may be why H30 is so widespread and has become a superbug. What makes it worse is that can go unnoticed in a patient until it causes significant damage.”

1 Johnson JR, Thuras P, Johnston BD, Weissman SJ, et. al. The Pandemic H30 Subclone of Escherichia coli Sequence Type 131 Is Associated With Persistent Infections and Adverse Outcomes Independent From Its Multidrug Resistance and Associations With Compromised Hosts. Clin Infect Dis. 2016 Jun 15;62(12):1529-36. doi: 10.1093/cid/ciw193. Epub 2016 Mar 29. PubMed PMID: 27025834; PubMed Central PMCID: PMC4885656.

 


Comments are closed here.


Related Articles

VA Researcher Seeks to Include Veterans’ Voices in Healthcare Decisions

SEATTLE—It’s a big job to ensure that VA’s healthcare system is equipped to provide the best possible care to veterans. It might be an even bigger job to make sure that veterans across the country... View Article

First-Ever Study Focuses on How Well VHA Cares for TIA Patients

INDIANAPOLIS — While many healthcare systems measure the quality of their stroke care, looking at performance early in the vascular disease process can help avoid acute events altogether.


U.S. Medicine Recommends


More From hhs and usphs

Department of Defense (DoD)

Telemedicine Allows Army, Indian Health Service to Expand Range of Diabetes Care

To reach the growing number of individuals in their care who have diabetes, both the Army and the Indian Health Service have aggressively adopted telemedicine

Pharmacists Play Big Role in More-Restrictive IHS Opioid Prescribing Rules

By Annette M. Boyle ROCKVILLE, MD—This summer, the Indian Health Service (IHS) instituted new rules for pharmacists and providers designed to reduce abuse and overuse of opioids, making it one of the first agencies to... View Article

HHS and USPHS

Stroke Kills Young American Indian/Alaska Natives at Twice Rate of Whites

By Annette M. Boyle ATLANTA – While three-quarters of stroke patients are older than 65, a “brain attack” can affect people of any age. For young American Indians and Alaskan Natives (AI/AN), that information is... View Article

Department of Defense (DoD)

Uniformed Pharmacists Take Half of Next Generation Pharmacist Awards

By Annette M. Boyle LAS VEGAS, NV — Of the 30 finalists in this year’s Next Generation Pharmacist awards, 30% worked in military or public health pharmacies, the strongest representation seen in the awards program.... View Article

Emphasizing Tradition to Reduce Diabetes in American Indians/Alaska Natives

By Annette M. Boyle Judy Goforth Parker, PhD, RN TAHLEQUAH, OK – Fifty years ago, the Cherokee had no word for diabetes. Today, American Indians and Alaska Native (AI/AN) adults have 2.3 times the risk... View Article

Subscribe to U.S. Medicine Print Magazine

U.S. Medicine is mailed free each month to physicians, pharmacists, nurse practitioners, physician assistants and administrators working for Veterans Affairs, Department of Defense and U.S. Public Health Service.

Subscribe Now

Receive Our Email Newsletter

Stay informed about federal medical news, clinical updates and reports on government topics for the federal healthcare professional.

Sign Up