SHREVEPORT, LA — Over the past decade, an increasing incidence of thromboembolic events has been observed in hospitalized patients with inflammatory bowel disease (IBD), including Crohn’s disease, according to a new study.

The study, published in the journal Vascular, was led by researchers from the Overton Brooks VAMC and Louisiana State University at Shreveport.1
For the study, researchers performed a national population-based study examining the incidence of both venous and arterial thromboembolic events in patients hospitalized with IBD over the past decade.

To do that, they performed a retrospective cross-sectional analysis using the Nationwide Inpatient Sample Database. Patients hospitalized with Crohn’s disease and ulcerative colitis were identified using ICD-9 codes. The incidence of clinically relevant venous thromboembolic events and arterial thromboembolic events including myocardial infarction, visceral ischemia, cerebrovascular accidents, and peripheral arterial events also was examined.

With 461,415 hospitalized inflammatory bowel disease patients identified during the study period, 28,820 had a diagnosis of a thromboembolic event, with an overall prevalence of 6%. Results indicated that the incidence of thromboembolic events in IBD patients rose from 5.65% in 2000 to 7.17% by 2009.

Of 18,270 (3.96%) patients who had an arterial thrombotic event, myocardial infarction (50%) was the most common, followed by visceral ischemia (25%) and cerebrovascular incidents (22%). Among the 11,083 (2.4%) patients identified to have had a venous thrombotic event, the most common manifestation was deep vein thrombosis (77%), followed by pulmonary embolism (32%) and portal vein thrombosis (3.9%).

“An increasing incidence of thromboembolic event in patients with inflammatory bowel disease was observed over the past decade,” the authors conclude. “Interestingly, there were more arterial thrombotic events in comparison to venous thrombotic events.”

1 Kuy S, Dua A, Chappidi R, Seabrook G, Brown KR, Lewis B, Rossi PJ, Lee CJ. The increasing incidence of thromboembolic events among hospitalized patients with inflammatory bowel disease. Vascular. 2014 Jul 1. pii: 1708538114541799. [Epub ahead of print] PubMed PMID: 24986868.