JACKSONVILLE, FL—As treatment options for chronic lymphocytic leukemia (CLL) multiply, physicians face an increasing array of sequencing options but have little guidance from clinical trials of the most effective order given each patient’s specific disease...
MHS Patients Receive Earlier Cancer Diagnoses Than General U.S. Population
Cancer patients treated within the MHS generally receive their diagnoses earlier than members of the general U.S. population covered by employee-provided insurance, Medicaid or without insurance.
CRC Screening Levels Too Low for Veterans With Anemia, Hematochezia
Already the second-leading cause of cancer death in the United States, colorectal cancer (CRC) is increasing in adults younger than 50. Early-age onset CRC (EAOCRC) is often diagnosed at later stages, which require more intense treatment, according to a new study.
MGUS Higher in Servicemembers, No Association Seen With Burn Pit Exposure
Individuals who have served in the U.S. military have about three times the risk of monoclonal gammopathy of undetermined significance (MGUS) as a similarly aged cohort in the Icelandic iStopMM study.
Mental Health Issues Increase Mortality in Some Veterans With AML
Venetoclax combinations are common treatments for individuals with acute myeloid leukemia (AML) who are unable to withstand the rigors of intensive induction chemotherapy.
BTK Inhibitors Provide Option for CLL Patients With Severe Renal Dysfunction
BTK inhibitors have proven to be a powerful tool in CLL treatment and have replaced chemoimmunotherapy as the preferred first-line treatment.
Evaluate Veterans With MGUS for Cardiovascular Disease
Monoclonal gammopathy of undetermined significance (MGUS) is not considered a hematological condition of concern, yet it is associated with lower overall survival. VA researchers led by Lawrence Liu, MD, of the St. Louis VAMC, explored whether the reduced life expectancy arose from an increased risk of cardiovascular events.
Dasatinib Fails to Improve Outcomes in B-ALL With ABL-Class Fusions
While most blood cancers affect people in their later years, B-cell acute lymphoblastic leukemia (B-ALL) strikes at a much earlier age. It is the most common hematologic malignancy in adults under the age of 40, the age range of 80% of U.S. servicemembers.
Deployment Linked to Longer Survival in Servicemembers, Veterans With NHL
A study presented at the 2023 ASH Conference, provided additional evidence for the healthy deployer effect, this time in individuals with non-Hodkin lymphoma.
Which Veterans Should Undergo SPEP Testing for Plasma Cell Dyscrasia?
Plasma cell dyscrasia affects up to 5% of adults. While often asymptomatic, its characteristic clonal expansion of bone marrow plasma cells can also indicate the presence of several hematological malignancies including multiple myeloma.
GLP-1 Use Reduces Risk of MGUS Progression in Some Veterans
Glucagon-like peptide 1 (GLP-1) receptor agonists have gained huge popularity as they have demonstrated the ability to substantially reduce both blood-glucose levels and weight. In addition, recent research suggests cardiovascular and renal benefits to their use in certain populations.
Agent Orange Increases CVD Risk in Veterans With Myeloproliferative Neoplasms
As Vietnam-era veterans move into the age range in which most myeloproliferative neoplasms (MPNs) develop, the VA has a keen interest in fully understanding the full impact of exposure to Agent Orange in veterans with these malignancies.
Million Veteran Program Study Pinpoints Concerns About Cannabis-Use Disorder
A study using data from the VA’s Million Veteran Program raised serious concerns about risks associated with cannabis use.
What Drives Higher CRC Rates, Worse Survival Among Blacks in U.S.?
If screening availability was equalized, the U.S. Black population would have a greater colorectal cancer incidence reduction than the White population, because of its slightly higher risk, according to a new study.
CRC Screening Too Low for Veterans With Anemia, Hematochezia
Among veterans with hematochezia, those aged 30 to 49 years were more likely to receive diagnostic testing than adults younger than 30 years of age.
MHS Patients Receive Earlier Diagnoses for Colorectal, Other Cancers
Military Health System patients tend to receive earlier diagnoses of colon cancer and other types of malignancies than members of the general U.S. population covered by insurance, especially Medicaid.
VHA Venous Thromboembolism Rates Low After Cancer Surgery
The rates of venous thromboembolism (VTE) diagnosis are low after major cancer surgery among veterans treated at the VHA, according to a recent study
Veterans Receiving Community Care for Prostate Cancer Might Be Overtreated
Has greater use of community care for veterans with prostate cancer meant more overtreatment?
Prostate Cancer Outcomes Better for Black, Hispanic Veterans with VHA Care
While a new study found that differences in outcomes from nonmetastatic castration-resistant prostate cancer (nmCRPC) exist based on race and ethnicity, Black and Hispanic men might have considerably improved survival rates when treated in an equal-access setting.
High Serum TARC Levels Predict Hodgkin Lymphoma Years Before Diagnosis
Could high levels of the chemokine TARC produced in tumor cells in classic Hodgkin lymphoma help predict the malignancy?
CLL Patients at the VA Receive Evidence-Based Treatments
Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are the most common forms of adult leukemia. More than 13,000 veterans have the diagnosis, which is associated with the toxic exposures included in the Pact Act, according to the VA.
B-cell lymphoma Presenting With Cranial Nerve Palsy, Mononeuritis Multiplex
Diagnosing B-cell lymphoma-associated mononeuritis multiplex, a peripheral neuropathy, can be challenging because of its rarity and the potential co-existence of other causes of the symptoms.
Older Age of DLBCL Patients Makes Treatment Challenging
Nearly one-half (49%) of all veterans in the United States are 65 years or older. Most of those older veterans (5.5 million) served during the Vietnam era, while 183,000 were World War II veterans, according to the 2021 American Community Survey (ACS).
Adenoma Detection Rate, Other Factors Important in Avoiding Advanced CRC
Polypectomy can reduce the incidence of and mortality from colorectal cancer, the second-leading cause of cancer death worldwide.
Determining Risk Factors Could Allow Early Colorectal Cancer Screening
There is a troubling increase in the incidence of CRC in adults younger than age 50 in the United States and other high-income countries.
Outcomes Are Similar for Laparoscopic, Robotic Surgeries for Colon Cancer
Which is better: laparoscopic or robotic surgery? That is the question raised in a recent study from Yale University School of Medicine and the VA Connecticut Healthcare System in West Haven.
No Increase in Cancer Identified With Use of Ranitidine Vs. Other H2RAs
In 2020, the U.S. Food and Drug Administration asked manufacturers to remove from the market all products containing ranitidine, a histamine-2 receptor antagonist (H2RA) that has been widely used to treat gastroesophageal reflux disease and peptic ulcer disease.
Pandemic Declines in Cancer Diagnoses Persisted for Two Years
Early in the COVID-19 pandemic, significant declines in cancer diagnoses occurred. But what happened from the end of 2020, the first year, and after widespread vaccination occurred?
VA Researchers Spotlight Racial, Ethnic Disparities in Liver Cancer Care
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is the fastest-growing cause of cancer-related death in the United States. But a new study points out that the burden of the often deadly cancer is not spread equally.
Healthy Older Veterans Not Getting CRC Screening That Could Benefit Them
Even though clinical guidelines recommend that clinicians selectively offer colorectal cancer (CRC) screening to older adults aged 76 to 85 years, taking into account their life expectancy, values, and preferences.