PHILADLPHIA—Broken bones can be a risk for patients with psoriatic arthritis, (PsA) according to a study that looked at the risk of fracture and osteoporosis among patients with that condition and with psoriasis, compared with the general population and patients with rheumatoid arthritis (RA).
The population-based cohort study, published in the Annals of Rheumatic Diseases, was performed in The Health Improvement Network in the UK using data from 1994 to 2014.1
Included in the study, which involved researchers from the Philadelphia VAMC, were patients aged 18-89 years with PsA or psoriasis and up to five unexposed controls matched by practice and start date within that practice. Patients with RA and matched controls were included for comparison.
For purposes of the study, severe psoriasis was defined by a code for psoriasis and either phototherapy or a systemic medication for psoriasis. Incidence and adjusted HRs (aHR) for fracture (all, hip, vertebral) also were calculated.
The study identified 9,788 patients with PsA, 158,323 with psoriasis and 821,834 controls.
Results indicate that patients with PsA had an elevated risk of all fracture for an adjusted HR of 1.26. Patients with mild psoriasis had elevated risk of all fractures, vertebral and hip fracture: aHR 1.07, 1.17 and 1.13, respectively.
Patients with severe psoriasis had significantly elevated risk of all fracture and vertebral fracture, however, for adjusted HRs of 1.26 and 2.23, respectively, researchers reported.
“PsA and psoriasis are associated with an elevated risk for fracture,” study authors concluded.
- Ogdie A, Harter L, Shin D, Baker J, Takeshita J, Choi HK, Love TJ, Gelfand JM. The risk of fracture among patients with psoriatic arthritis and psoriasis: a population-based study. Ann Rheum Dis. 2017 May;76(5):882-885. doi: 10.1136/annrheumdis-2016-210441. Epub 2017 Jan 16. PubMed PMID: 28093419; PubMed Central PMCID: PMC5384863.