b'Figure 2.PheWAS for sucidality phenotypes in CSP #572.PheWAS resulted for suicidal behaviors across 1,000 disease categories. The dotted line indicates an approximate Bonferroni adjusted p-value threshold for the number of Phecodes tested.Source: Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder; National Library of Medicine; https://pubmed.ncbi.nlm.nih.gov/36945597/self-reported SB and ideation using the Columbiaantidepressants, antipsychotics, etc.), the researchers SuicideSeverityRatingScale(C-SSRS).Theadvised. PGS for externalizing behaviors, smoking, cross-sectional data were integrated with electronicsuicide attempt, and major depressive disorder were healthrecords(EHR),andcomparedbylifetimealso associated with attempt and ideation.diagnoses,treatmenthistories,follow-upscreen- While the authors said they didnt find any signifi-ings,andmortalitydata. Availablegenomicdatacant loci among individuals with a diagnosed mental was used to construct polygenic scores (PGS) forillness,self-reportedSBwerestronglyassociated traitsrelatedtopsychiatricdisorders,substancewith clinical variables across several areas.use, and cognition, while exploratory genomewideOverall,clinicalandpolygenicanalysespoint association studies were performed to identify andto sequelae of substance-use related behaviors and prioritize specific loci. other psychiatric comorbidities as strong correlates The study pointed out that only 20% of veteransof prior and subsequent SB, the study concluded. who self-reported SB had a corroborating ICD-9/10Nonetheless,pastSBwasfrequentlynotdocu-codeintheelectronichealthrecord.Inaddition,mented in clinical settings, underscoring the value of more than 20% of veterans who denied prior behav- regular screening based on direct, in-person assess-iors reported new-onset SB at follow-up.ments, especially among high-risk individuals.SB were associated with a range of psychiatric andSerious mental illness also has a detrimental effect non-psychiatricdiagnoses,andwithtreatmentwithonphysicianfunctionofveterans,accordingto specificclassesofpsychotropicmedications(e.g.,another recent study.Continued on Page 38 u29'