b'Figure 4.Associations of PGS with suicidality behaviors in SCZ and BPI.For each polygenic score, the odd ratio (per unit increase) to the best-performing P-value threshold is shown. Displayed results are based on the EA cohort, and adjusted for diagnosis, sex, and age.Source: Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder; National Library of Medicine; https://pubmed.ncbi.nlm.nih.gov/36945597/u From Page 29A study led by the VA Providence, RI, Healthcareworse compared to propensity-score matched older Systemandthe AlpertMedicalSchoolofBrownveteranswithoutSMIwithstatisticallysignificant University sought to characterize the physical func- differences on chair stands, 6-minute walk test, and tionofolderveteranswithseriousmentalillness10-meter walk, the authors wrote.(SMI)acrossendurance,strengthandmobilityThe study concluded that older veterans with SMI domains. havecompromisedstrength,mobilityandendur-The retrospective analysis of clinical performanceance. The authors urged that physical function be a data focused on participants in the VHAs Gerofitcore component of screening and treatment for this program, a national outpatient supervised exercisepopulation.program for older veterans. Included were 166 vet- 1Sun F, Stock EM, Copeland LA, Zeber JE, et. al. Polypharmacy erans aged 60 and older with SMI and 1,441 with- with antipsychotic drugs in patients with schizophrenia: trends in out who were enrolled in eight national Gerofit sitesmultiple health care systems. Am J Health Syst Pharm. 2014 May between 2010 and 2019. Results were published in1;71(9):728-38. doi: 10.2146/ajhp130471. PMID: 24733136; PMCID: the American Journal of Geriatric Psychiatry. 4 PMC4432466.Researchersassessedperformancemeasuresof2Jester DJ, Thomas ML, Sturm ET, Harvey PD, et. al. Review of Major Social Determinants of Health in Schizophrenia-Spectrum Psychotic physicalfunctioncoveringendurance(6-minuteDisorders: I. Clinical Outcomes. Schizophr Bull. 2023 Apr 6:sbad023. walktest),strength(chairstands,armcurls),anddoi: 10.1093/schbul/sbad023. Epub ahead of print. PMID: 37022779.mobility (10-meter walk, 8-foot up-and-go) admin- 3Bigdeli TB, Barr PB, Rajeevan N, Graham DP, et. al. Million Veteran istered at Gerofit enrollment. The goal was to con- Program (MVP); Cooperative Studies Program (CSP) #572; Huang struct functional profiles of older veterans with SMIGD, Concato J, Siever LJ, DeLisi LE, Kimbrel NA, Beckham JC, Swann AC, Kosten TR, Fanous AH, Aslan M, Harvey PD. Correlates compared to other veterans. of suicidal behaviors and genetic risk among United States veterans Results indicated that older veterans with SMI per- with schizophrenia or bipolar I disorder. medRxiv [Preprint]. 2023 formed worse on all measures of function, includ- Mar 8:2023.03.06.23286866. doi: 10.1101/2023.03.06.23286866. ing chair stands, arm curls, 10-meter walk, 6-minutePMID: 36945597; PMCID: PMC10029042.walk test, 8-foot up-and-go, compared to age- and4Browne J, Elbogen EB, Mueser KT, Rudolph JL, et. al. Physical sex-basedreferencescoreswithstatisticallysig- Function Assessment of Older Veterans With Serious Mental Illness. Am J Geriatr Psychiatry. 2023 Mar 2:S1064-7481(23)00235-X. doi: nificantdifferencespresentinthemalesample.10.1016/j.jagp.2023.02.048. Epub ahead of print. PMID: 36941144.Functional performance of those with SMI was also 38'