b'Source: The Association of Improved Overall Survival with NSAIDs in Non-Small Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors. Clin Lung Cancer. 2023 Jan 21:S1525-7304(23)00001-3. doi: 10.1016/j.cllc.2022.12.013. Epub ahead of print. PMID: 36804711u From Page 102with NSAIDs could theoretically enhance anti-tumorIt is hard to extrapolate from this kind of retrospec-immunity, he said.tive data the difference in survival because there are The increased survival associated with diclofenacso many different confounding factors that may be use in particular might be due to its unique effects onaffecting those numbers.cellular lactate secretion, he said. In theory decreas- Eventually prescribing NSAIDs might be found to ing lactate in the tumor microenvironment can alsoimprove the efficacy of ICI in patients with NSCLC. enhance tumor immunity. But until we get a clinical trial I dont know that I think it is a promising finding in that we foundwe can make a recommendation regarding NSAIDs a classof drug that is safe, affordable and widelyone way or another, said Sebastian, adding that he available that may improve survival in this grouphopes such a trial could be started soon. ofpatients,hesaid,whilealsonotingthatthe1Sebastian NT, Stokes WA, Behera M, Jiang R, Gutman DA, Huang study showed a correlation and correlation is not aZ, Burns A, Sukhatme V, Lowe MC, Ramalingam SS, Sukhatme VP, causation. Moghanaki D. The Association of Improved Overall Survival with I think the only way to really properly determine ifNSAIDs in Non-Small Cell Lung Cancer Patients Receiving Im-mune Checkpoint Inhibitors. Clin Lung Cancer. 2023 Jan 21:S1525-NSAIDs can improve survival in this group is to do a7304(23)00001-3. doi: 10.1016/j.cllc.2022.12.013. Epub ahead of randomized controlled clinical trial, Sebastian said.print. PMID: 36804711.104'