Mistsubishi Radicava page 1 of 2 4C (near ALS Symptoms) Supporting the Needs of Veterans With ALS Over 600 Veterans are on RADICAVA ORS.7,c,d RADICAVA ORS is on the VA National Formulary subject to local prior authorization criteria.1,a Veterans with ALS may be eligible for treatment with RADICAVA ORS and other benefits from VA.1-6,b Veterans can check with their local VHA enrollment center or military treatment facility DEERS office for more information on nonmedical benefits.1-6,b a This product is on the VA National Formulary and may have prior authorization requirements that are managed at the local facility level. Contact your local VA pharmacy for additional instruction on obtaining a prior authorization for this medication. b A service connection for any Veteran who develops the disease at any time after separation from service.9 c Based on RADICAVA ORS prescriptions submitted in the US as of August 2025. Not independently verified.7 d Data on file. Shionogi Inc. Based upon data through August 31, 2025.7 ALS=amyotrophic lateral sclerosis; DEERS=Defense Enrollment Eligibility Reporting System; FDA=Food and Drug Administration; VA=Veterans Affairs; VHA=Veterans Health Administration. INDICATION RADICAVA ORS® (edaravone) is indicated for the treatment of amyotrophic lateral sclerosis (ALS). IMPORTANT SAFETY INFORMATION Hypersensitivity Reactions RADICAVA ORS® (edaravone) is contraindicated in patients with a history of hypersensitivity to edaravone or any of the inactive ingredients of this product. Hypersensitivity reactions (redness, wheals, and erythema multiforme) and cases of anaphylaxis (urticaria, decreased blood pressure, and dyspnea) have occurred. Patients should be monitored carefully for hypersensitivity reactions. If hypersensitivity reactions occur, discontinue RADICAVA ORS, treat per standard of care, and monitor until the condition resolves. Sulfite Allergic Reactions RADICAVA ORS contains sodium bisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown but occurs more frequently in asthmatic people. Adverse Reactions The most common adverse reactions (≥10%) reported in RADICAVA® (edaravone)-treated patients and at least 2% more frequently than placebo were contusion (15% vs 9%), gait disturbance (13% vs 9%), and headache (10% vs 6%), respectively. In an open label study, fatigue was also observed in 7.6% of patients receiving RADICAVA ORS. Pregnancy Based on animal data, RADICAVA ORS may cause fetal harm. To report suspected adverse reactions or product complaints, contact Shionogi Inc., at 1-888-292-0058. You may also report suspected adverse reactions to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Please see Brief Summary of full Prescribing Information on adjacent page, and the full Prescribing Information at www.radicavaors.com. RADICAVA ORS IS ON THE VA NATIONAL FORMULARY1,a Learn more about our Veteran support at radicavahcp.com/for-veterans or SCAN the QR code. As the only FDA-approved oral formulation of edaravone, RADICAVA ORS offers Veterans with ALS an oral option that may fit their life’s routines.8 References: 1. US Department of Veterans Affairs. VA formulary advisor. Accessed September 19, 2025. https://www.va.gov/formularyadvisor/drugs/4041481-EDARAVONE-SUSP-ORAL 2. US Department of Veterans Affairs. VA makes specially adaptive housing grant eligibility automatic for veterans and servicemembers living with ALS [news release]. Published March 19, 2014. Accessed September 19, 2025. https://www.va.gov/opa/ pressrel/pressrelease.cfm?id=2530 3. US Department of Veterans Affairs. Current Veterans disability compensation rates. Updated December 2, 2024. Accessed September 19, 2025. https://www.va.gov/disability/ compensation-rates/veteran-rates 4. US Department of Veterans Affairs. Dependency and indemnity compensation. Updated May 2022. Accessed September 19, 2025. https://benefits.va.gov/BENEFITS/factsheets/ survivors/dic.pdf 5. US Department of Veterans Affairs. Special claims. Updated December 26, 2023. Accessed September 19, 2025. https://www.va.gov/disability/eligibility/special-claims 6. US Department of Veterans Affairs. Automobile allowance and adaptive equipment. Updated April 14, 2025. Accessed September 19, 2025. https://www.va.gov/disability/eligibility/special-claims/automobile-allowance-adaptive-equipment 7. Data on file. Shionogi Inc. 8. RADICAVA and RADICAVA ORS Prescribing Information. Florham Park, NJ; Shionogi Inc.; 2026. 9. US Department of Veterans Affairs. ALS awareness month. Accessed September 19, 2025. https://www.va.gov/marion-health-care/stories/als-awareness-month
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