Clinical Topics

Parkinson’s Drug Not Associated With Higher Prostate Cancer Risk

by U.S. Medicine

September 9, 2018

SILVER SPRING, MD—An increased incidence of prostate cancer was observed in Parkinson’s disease (PD) patients treated with entacapone during a pre-approval randomized clinical trial, according to a new study which noted that the relationship had not yet been intensely investigated.

Entacapone is used with levodopa and carbidopa to prolong the effects in the brain.

In response, researchers from the U.S. Food and Drug Administration (FDA) sought to investigate whether entacapone is associated with prostate cancer and whether the drug is linked to advanced disease at the time of cancer diagnosis. Results were published in the journal Parkinsonism & Related Disorders.1

The FDA team used data from the VA’s healthcare system, focusing on Parkinson’s patients treated with add-on entacapone or add-on dopamine agonist/monoamine oxidase B inhibitors between January 2000 and December 2014. Veterans were followed on treatment for occurrence of prostate cancer, which was identified through linkage to the VA cancer registry.

Overall, 17,666 patients, mean age 74, met study criteria, with the entacapone-treated group including 5,257 subjects. Over mean follow-up time of 3.1 and 4.0 years in the entacapone and control cohort, respectively, 23 prostate cancer cases occurred in the entacapone cohort and 97 in the control cohort.

Results indicated that the overall incidence of prostate cancer was 1.8 per 1,000 person-years of risk. No difference in risk of prostate cancer was detected between the cohorts for increased duration of entacapone intake (adjusted HR: 1.08; 95% confidence interval: 0.46–2.51 for cumulative exposure of two or more years). Furthermore, researchers noted, Time since starting drug therapy and cumulative dose (mg) also did not point to a difference in prostate cancer risk between cohorts.

“Prolonged therapy with entacapone was not associated with increased prostate cancer incidence; however, findings suggest a higher severity of prostate cancer,” study authors concluded.

1. Major JM, Dong D, Cunningham F, By K, Hur K, Shih DC, Jiang R, Podskalny GD, Wei X, Pinheiro S, Bird ST, Keeton S, Graham DJ. Entacapone and prostate cancer in Parkinson’s disease patients: A large Veterans Affairs healthcare system study. Parkinsonism Relat Disord. 2018 May 5. pii: S1353-8020(18)30220-7. doi: 10.1016/j.parkreldis.2018.04.035. [Epub ahead of print] PubMed PMID: 29759929.


Comments are closed here.


Related Articles

Effective Metrics Help VA Exceed National Goal for Colorectal Cancer Screening

More Than 80% of Patients Meet Recommendations LOS ANGELES—More than four out of five veterans eligible for colorectal cancer screening have been screened, putting the largest healthcare system in the United States among the top... View Article

More Options, Better Survival for Veterans With Metastatic Pancreatic Cancer

ALBANY, NY—Pancreatic cancer remains one of the deadliest malignancies in the United States, but new therapies can extend life and improve quality of life for many patients. That is especially the case at the VA,... View Article


U.S. Medicine Recommends


More From oncology

Oncology

Effective Metrics Help VA Exceed National Goal for Colorectal Cancer Screening

More Than 80% of Patients Meet Recommendations LOS ANGELES—More than four out of five veterans eligible for colorectal cancer screening have been screened, putting the largest healthcare system in the United States among the top... View Article

Oncology

More Options, Better Survival for Veterans With Metastatic Pancreatic Cancer

ALBANY, NY—Pancreatic cancer remains one of the deadliest malignancies in the United States, but new therapies can extend life and improve quality of life for many patients. That is especially the case at the VA,... View Article

Oncology

Military Risks for Ocular Surface Squamous Neoplasia

MIAMI—While a variety of risk factors have been evaluated in ocular surface squamous neoplasia, few studies have assessed risk factors specific to the armed forces veteran population. A report in the journal Eye and Vision... View Article

Oncology

Antibiotics Appear to Inhibit Tumor Activity in CTCL

AARHUS, DENMARK—Do CD4 T cell responses to  Staphylococcus aureus inadvertently enhance neoplastic progression in models of skin cancer and cutaneous T cell lymphoma? A prospective study in the journal Blood examined that question, exploring the... View Article

Oncology

Lower Dose Cisplatin Preferable in Squamous Cell Carcinoma

PHILADELPHIA—Chemoradiotherapy is commonly used for nonoperative treatment of locally advanced head and neck squamous cell carcinoma. The issue, according to a recent study, is that the standard dose of 100 mg/m2 cisplatin every three weeks is... View Article

Subscribe to U.S. Medicine Print Magazine

U.S. Medicine is mailed free each month to physicians, pharmacists, nurse practitioners, physician assistants and administrators working for Veterans Affairs, Department of Defense and U.S. Public Health Service.

Subscribe Now

Receive Our Email Newsletter

Stay informed about federal medical news, clinical updates and reports on government topics for the federal healthcare professional.

Sign Up