Genetic Mutations Affecting Response to Drugs Are Common in Veterans

Genetic Mutations Affecting Response to Drugs Are Common in Veterans

SALT LAKE CITY — A massive VA study revealed that 99% of veterans have at least one genetic mutation known to affect response to specific drugs, including some commonly prescribed antidepressants, anticoagulants, antivirals, oncology medications and statins. That raises the question of who should be tested for which variants and when, which has stirred lively debate within the VA.

Combat PTSD/TBI Increases Amygdala Size in Military Patients

SAN DIEGO — The region of the brain that processes fear, anxiety, aggression and similar emotions is larger in veterans and active-duty service members with combat-related post-traumatic stress disorder and mild traumatic brain injury than those with brain injuries only.

Debate Continues on Esketamine Efficacy and Safety for Depression Treatment

Debate Continues on Esketamine Efficacy and Safety for Depression Treatment

PHILADELPHIA—Is esketamine a revolutionary treatment for depression or just another moderately effective adjunctive medication with some potentially serious risks? The VA’s Medical Advisory Panel leaned toward the latter position when it decided in June to approve the use of esketamine on a nonformulary basis for individuals who have previously failed at least two trials of other antidepressants.

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