Equations that estimate 10-year risk of atherosclerotic cardiovascular disease (ASCVD) appear to have overestimated the number of U.S. adults eligible for primary prevention statin therapy, according to a new study.
Iron Deficiency Independently Association With Heart Failure Development
What is the relationship of iron status with incident heart failure in community-dwelling older adults, without regard to their kidney function?
Propofol Is Impairment Risk Factor in Children With ALL
New research evaluated the effect of cumulative exposure to anesthesia on neurocognitive outcomes among a multicenter cohort of children with acute lymphocytic leukemia (ALL).
Almost 1 in 11 U.S. Military Casualties Received Warm Fresh Whole Blood
To help save lives, especially in battlefield situations, the U.S. military has frequently used a so-called walking blood bank to obtain warm, fresh whole blood (WFWB).
Study Emphasizes Importance of β-cell Function Loss in T2D Progression
For the estimated 1 in 10 Americans—or 1 in 4 veterans—with Type 2 diabetes, keeping blood glucose levels in the near-normal range reduces the risk of complications such as heart, kidney and eye disease.
Reducing the Number of PPI Prescriptions: Benefits and Potential Pitfalls
One of the most commonly prescribed classes of drugs, proton pump inhibitors (PPIs), reduces the risk of gastrointestinal bleeding in certain patients at increased risk. Most PPI prescriptions are written for other reasons, however. In fact, an estimated 25-70% of PPI users might not have an appropriate indication.
New Study Defines Clinically Important Measures of Diabetes Distress
The term “diabetes distress” is used to describe the emotional response to living with diabetes, a life-threatening illness that requires chronic and demanding self-management.
No Racial Differences in DLBCL Treatment Within VA Healthcare System
No statistically significant racial differences in diffuse large B-cell lymphoma (DLBCL) outcomes were found for patients treated within the VHA, according to recent research.
Very Elderly Patients Fare Much Worse When Treated for DLBCL
Diffuse large B-cell lymphoma (DLBCL) becomes much more difficult to treat in older patients, according to a new study suggesting that more adults of advanced age be included in clinical trials for new agents.
Despite Disparities, Making a Difference for Veterans With Relapsed DLBCL
DURHAM, NC—Recent Food and Drug Administration approvals of chimeric antigen receptor (CAR) T cell therapies and novel immunotherapies have helped to significantly improve outcomes for patients with relapsed and refractory diffuse large B cell lymphoma (R/R DLBCL)....
More Diverse Dataset Raises Questions about MGUS Risk Models
Patients with monoclonal gammopathy of undetermined significance (MGUS) have been thought to have a less than 1% chance of progressing to multiple myeloma as long as their M-protein levels are below 1.5 g/dL.
For CLL, BTK Inhibitors Appear to Extend Time to Next Line Most
JACKSONVILLE, FL—As treatment options for chronic lymphocytic leukemia (CLL) multiply, physicians face an increasing array of sequencing options but have little guidance from clinical trials of the most effective order given each patient’s specific disease...
Gulf War Illness Reduces White Blood Cells’ Ability to Make Energy
The ability of white blood cells to make energy is significantly reduced in Gulf War Illness (GWI), which affects approximately 250,000 U.S. veterans, according to a new study finding a measurable biochemical difference in veterans who have the disease.
CRC Screening Levels Too Low for Veterans With Anemia, Hematochezia
Already the second-leading cause of cancer death in the United States, colorectal cancer (CRC) is increasing in adults younger than 50. Early-age onset CRC (EAOCRC) is often diagnosed at later stages, which require more intense treatment, according to a new study.
MGUS Higher in Servicemembers, No Association Seen With Burn Pit Exposure
Individuals who have served in the U.S. military have about three times the risk of monoclonal gammopathy of undetermined significance (MGUS) as a similarly aged cohort in the Icelandic iStopMM study.
Mental Health Issues Increase Mortality in Some Veterans With AML
Venetoclax combinations are common treatments for individuals with acute myeloid leukemia (AML) who are unable to withstand the rigors of intensive induction chemotherapy.
BTK Inhibitors Provide Option for CLL Patients With Severe Renal Dysfunction
BTK inhibitors have proven to be a powerful tool in CLL treatment and have replaced chemoimmunotherapy as the preferred first-line treatment.
Evaluate Veterans With MGUS for Cardiovascular Disease
Monoclonal gammopathy of undetermined significance (MGUS) is not considered a hematological condition of concern, yet it is associated with lower overall survival. VA researchers led by Lawrence Liu, MD, of the St. Louis VAMC, explored whether the reduced life expectancy arose from an increased risk of cardiovascular events.
Dasatinib Fails to Improve Outcomes in B-ALL With ABL-Class Fusions
While most blood cancers affect people in their later years, B-cell acute lymphoblastic leukemia (B-ALL) strikes at a much earlier age. It is the most common hematologic malignancy in adults under the age of 40, the age range of 80% of U.S. servicemembers.
Deployment Linked to Longer Survival in Servicemembers, Veterans With NHL
A study presented at the 2023 ASH Conference, provided additional evidence for the healthy deployer effect, this time in individuals with non-Hodkin lymphoma.
Which Veterans Should Undergo SPEP Testing for Plasma Cell Dyscrasia?
Plasma cell dyscrasia affects up to 5% of adults. While often asymptomatic, its characteristic clonal expansion of bone marrow plasma cells can also indicate the presence of several hematological malignancies including multiple myeloma.
GLP-1 Use Reduces Risk of MGUS Progression in Some Veterans
Glucagon-like peptide 1 (GLP-1) receptor agonists have gained huge popularity as they have demonstrated the ability to substantially reduce both blood-glucose levels and weight. In addition, recent research suggests cardiovascular and renal benefits to their use in certain populations.
Agent Orange Increases CVD Risk in Veterans With Myeloproliferative Neoplasms
As Vietnam-era veterans move into the age range in which most myeloproliferative neoplasms (MPNs) develop, the VA has a keen interest in fully understanding the full impact of exposure to Agent Orange in veterans with these malignancies.
Cardioprotective Drugs Not Also Used in Patients Needing Them Most
Even though the overall uptake of cardioprotective antihyperglycemic drugs has increased as second-line treatments for Type 2 diabetes mellitus, over the last decade, patients who actually have cardiovascular disease were less likely to be prescribed them compared to those without CVD.
Strict LDL-C Lowering Linked to Diabetes Progression
While some guidelines recommend statin use to achieve low-density lipoprotein cholesterol (LDL-C) goal under 70 mg/dL for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in patients at higher risk, others recommend against a target LDL-C level.
Glycemic Control Not Affected Much By Neighborhood Factors
How do demographic, social and geographic factors affect glycemic control over time in veterans newly diagnosed with diabetes?
Anemia Raises Dementia Risk in Veterans With CKD
What is the role of anemia in risk of dementia in veterans with chronic kidney disease?
New Research Suggested That Veterans Exposed to Agent Orange Have Increased Risk of Developing Progressive Blood Cancers, Such as MPNs
For the first time, new research findings have suggested that veterans exposed to Agent Orange might be at increased risk of developing progressive blood cancers, such as myeloproliferative neoplasms (MPNs).
Early Surgical Intervention, Blood Product Use in Battlefield Casualties
In planning and preparing for the future possibility of large-scale combat operations, military medicine might have to decide which wounded warriors can have delayed evacuations. One issue is the need for blood products.
Repository Offers Clues About Young Adult Classical HL
Immune abnormalities persist in young adult classical Hodgkin lymphoma (YAcHL) patients long after cure. Yet, new research presented at the most recent Annual ASH Meeting and Exposition in New Orleans pointed out the difficulties in assessing whether those issues existed prior to diagnosis.